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中文名稱： 兔抗PAK1/2/3(Ab-423/402/421) 多克隆抗體
英文名稱： Anti-PAK1/2/3(Ab-423/402/421) rabbit polyclonal antibody
別 名： PAKalpha/PAK65; PAKgamma/bPAK; MRX30; MRX47; OPHN3; hPAK3; CDKN1A; PAK3beta
抗 原： PAK1/2/3(Ab-423/402/421)
儲 存： 冷凍（-20℃） 避光
宿 主： Rabbit
反應種屬： Human
相關(guān)類別： 一抗
標 記 物： Unconjugate
克隆類型： rabbit polyclonal
技術(shù)規(guī)格
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Background: |
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development. |
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Applications: |
WB, IHC |
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Name of antibody: |
PAK1/2/3(Ab-423/402/421) |
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Immunogen: |
Synthesized non-phosphopeptide derived from human PAK1/2/3 around the phosphorylation site of threonine 423/402/421 (R-S-T(p)-M-V). |
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Full name: |
p21 protein (Cdc42/Rac)-activated kinase 1/2/3 |
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Synonyms： |
PAKalpha/PAK65; PAKgamma/bPAK; MRX30; MRX47; OPHN3; hPAK3; CDKN1A; PAK3beta |
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SwissProt: |
Q13153/Q13177/O75914 |
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IHC positive control: |
Human brain tissue |
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IHC Recommend dilution: |
50-100 |
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WB Predicted band size: |
61/58/62 kDa |
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WB Positive control: |
NIH/3T3 cells lysate |
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WB Recommended dilution: |
500-3000 |
